Dan Agbese was educated at the University of Lagos and Columbia University, New York. He holds a Bachelor of Arts and Master of Science degrees in mass communication and journalism. He began his journalism career at the New Nigerian Newspapers, Kaduna, and has edited two national newspapers, The Nigeria Standard and the New Nigerian. He and his three close friends in the news media, Ray Ekpu, Yakubu Mohammed, and the late Dele Giwa, founded the trail-blazing weekly newsmagazine in Nigeria, Newswatch, in 1984. He held various editorial positions in the magazine and was Editor-in-Chief of the magazine.
Agbese is a well-regarded and respected columnist in Nigeria. He wrote popular columns for the Nigeria Standard and Newswatch magazine. He is the author of Fellow Nigerians: Turning Points in the Political History of Nigeria, 1966 - 1999; Nigeria their Nigeria, Ibrahim Babangida: The Military, Politics and Power in Nigeria, Footprints on Marble: Murtala H. Nyako, The Six Military Governors Voices of History, Conversation with History and three journalism textbooks, Style: A Guide to Good Writing, The Reporter's Companion and The Columnist's Companion: The Art and Craft of Column Writing. He has also contributed chapters to several books on Nigerian politics.
Agbese's much-admired style of writing has been the subject of a thesis by students in the University of Jos, the University of Ibadan, and Benue State University.